General Information

  • ID:  hor006822
  • Uniprot ID:  M0R8L2??28-116)
  • Protein name:  Spexin
  • Gene name:  AGRP; AGRT, ART;
  • Organism:  Rattus norvegicus
  • Family:  Spexin family
  • Source:  Animal
  • Expression:  Widely expressed; predominantly expressed in epithelial cells in the skin; respiratory; digestive; urinary and reproductive systems; retina; adrenal gland and various brain regions. In the adrenal gla
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Rattus; Rattus norvegicus (Rat)
  • GO MF:  GO:0005737 cytoplasm; GO:0031045 dense core granule; GO:0005615 extracellular space; GO:0030133 transport vesicle
  • GO BP:  GO:0031765 type 2 galanin receptor binding; GO:0005184 neuropeptide hormone activity; GO:0031766 type 3 galanin receptor binding
  • GO CC:  GO:0044539 long-chain fatty acid import into cell; GO:1904306 positive regulation of gastro-intestinal system smooth muscle contraction; GO:0045944 positive regulation of transcription by RNA polymerase II; GO:0032099 negative regulation of appetite

Sequence Information

  • Sequence:  PQRLSEKRNWTPQAMLYLKGAQGHRFISDQSRRKELADRPPPERRNPNLQLLTLPEAAALFLASLEKPQKDEGGDFDKSKLLEDRRFYW
  • Length:  89
  • Propeptide:  MKGPSILAVAALALLLVLSVLENSSGAPQRLSEKRNWTPQAMLYLKGAQGHRFISDQSRRKELADRPPPERRNPNLQLLTLPEAAALFLASLEKPQKDEGGDFDKSKLLEDRRFYW
  • Signal peptide:  MKGPSILAVAALALLLVLSVLENSSG
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  SPX can be a neurotransmitter/neuromodulator and an endocrine factor;spexin reduces the rate of adrenocortical cell proliferation and may evoke an increase in aldosterone and glucocorticoid secretion in some rat adrenocortical cell cultures;SPX protects e
  • Mechanism:  SPX can be a neurotransmitter/neuromodulator and an endocrine factor;spexin reduces the rate of adrenocortical cell proliferation and may evoke an increase in aldosterone and glucocorticoid secretion in some rat adrenocortical cell cultures;SPX protects energy and mitochondrial homeostasis of cardiomyocytes during hypoxia; Spexin incubation in vitro significantly inhibited facilitated fatty acid (FA) uptake into DIO mouse adipocytes.
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    NA

Physical Information

Mass: Formula:
Absent amino acids: Common amino acids:
pI: Basic residues:
Polar residues: Hydrophobic residues:
Hydrophobicity: Boman Index:
Half-Life: Half-Life Yeast:
Half-Life E.Coli: Aliphatic Index
Instability Index: Extinction Coefficient cystines:
Absorbance 280nm:

Literature

  • PubMed ID:  NA
  • Title:  NA